Vaniqa Cream is used for:

Slowing the growth of unwanted facial hair in women.

Vaniqa Cream is an enzyme inhibitor. It works by blocking an enzyme necessary for hair to grow.

Do NOT use Vaniqa Cream if:

• you are allergic to any ingredient in Vaniqa Cream

Contact your doctor or health care provider right away if any of these apply to you.

Before using Vaniqa Cream:

Some medical conditions may interact with Vaniqa Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have scraped or broken skin, or sores on the affected area

Some MEDICINES MAY INTERACT with Vaniqa Cream. However, no specific interactions with Vaniqa Cream are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vaniqa Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Vaniqa Cream:

Use Vaniqa Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

• Vaniqa Cream comes with an additional patient leaflet. Read it carefully and reread it each time you get this medicine refilled. Ask your doctor or pharmacist any questions that you may have about Vaniqa Cream.
• Apply a thin layer of Vaniqa Cream to the affected areas of the face and under the chin, at least 5 minutes after hair removal (eg, plucking, shaving). Rub in thoroughly. Do not wash the treated area for at least 4 hours. Wait at least 8 hours between applications of Vaniqa Cream.
• Cosmetics or sunscreens may be applied to treated areas after Vaniqa Cream has dried.
• If you miss a dose of Vaniqa Cream, skip the missed dose and return to your regular dosing schedule. Do not apply 2 doses at once.

Ask your health care provider any questions you may have about how to use Vaniqa Cream.

Important safety information:

• Vaniqa Cream is for external use only. Avoid contact with the vaginal area, eyes, nose, or mouth.
• Vaniqa Cream does not remove hair. You will need to continue your routine method of hair removal while using Vaniqa Cream.
• You may need to use Vaniqa Cream for at least 4 to 8 weeks before you begin to see improvement. If your symptoms do not improve or become worse, contact your doctor.
• Use Vaniqa Cream with extreme caution in CHILDREN younger than 12 years of age. Safety and effectiveness in this age group have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Vaniqa Cream during pregnancy. It is unknown if Vaniqa Cream is excreted in breast milk. If you are or will be breast-feeding while you are using Vaniqa Cream, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Vaniqa Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness; skin tingling; temporary stinging or burning.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding or irritation of the skin.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Vaniqa Cream may be harmful if swallowed. Symptoms may include dizziness; facial swelling; hair loss; headache; hearing loss; loss of appetite; seizures; unusual bruising or bleeding; upset stomach; weakness.

Proper storage of Vaniqa Cream:

Store Vaniqa Cream at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Vaniqa Cream out of the reach of children and away from pets.

General information:

• If you have any questions about Vaniqa Cream, please talk with your doctor, pharmacist, or other health care provider.
• Vaniqa Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Vaniqa Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Naprosyn is used for:

Treating rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and juvenile arthritis. It is used to treat tendonitis, bursitis, gout, menstrual cramps, or mild to moderate pain. It may also be used for other conditions as determined by your doctor.

Naprosyn is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Naprosyn if:

• you are allergic to any ingredient in Naprosyn
• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg, ibuprofen, celecoxib)
• you have recently had or will be having bypass heart surgery
• you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Naprosyn :

Some medical conditions may interact with Naprosyn . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)
• if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation
• if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
• if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you are on a low salt (sodium) diet, you drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Naprosyn . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased
• Probenecid because it may increase the risk of Naprosyn ’s side effects
• Cyclosporine, hydantoins (eg, phenytoin), lithium, methotrexate, quinolones (eg, ciprofloxacin), sulfonamides (eg, sulfamethoxazole), or sulfonylureas (eg, glipizide) because the risk of their side effects may be increased by Naprosyn
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), beta-blockers (eg, propranolol), or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Naprosyn

This may not be a complete list of all interactions that may occur. Ask your health care provider if Naprosyn may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Naprosyn :

Use Naprosyn as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Naprosyn comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Naprosyn refilled.
• Take Naprosyn by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach of bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
• Take Naprosyn with a full glass of water (8 oz/240 mL) as directed by your doctor.
• If you take antacids, cholestyramine, or sucralfate, ask your doctor or pharmacist how to take them with Naprosyn .
• If you miss a dose of Naprosyn and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Naprosyn .

Important safety information:

• Naprosyn may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Naprosyn with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Serious stomach ulcers or bleeding can occur with the use of Naprosyn . Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Naprosyn with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Naprosyn has naproxen in it. Before you start any new medicine, check the label to see if it has naproxen or any other NSAID (eg, ibuprofen) in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do not take aspirin while you are using Naprosyn unless your doctor tells you to.
• Do not switch between different forms of Naprosyn (eg, tablets, suspension) unless your doctor tells you to. They may not provide the same amount of medicine to your body.
• Naprosyn may interfere with certain lab tests. Be sure your doctor and lab personnel know that you take Naprosyn .
• Lab tests including kidney function, complete blood cell counts, and blood pressure, may be performed while you use Naprosyn . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Naprosyn with caution in the ELDERLY; they may be more sensitive to its effects, especially stomach bleeding and kidney problems.
• Naprosyn should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Naprosyn may harm the fetus. Do not use it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Naprosyn while you are pregnant. Naprosyn should not be used during labor. Naprosyn is found in breast milk. Do not breast-feed while taking Naprosyn .

Possible side effects of Naprosyn :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; gas; headache; heartburn; nausea; stomach upset; stuffy nose.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm ), or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea or stomach pain; slow or troubled breathing; unusual bleeding or bruising; vomit that looks like coffee grounds.

Proper storage of Naprosyn :

Proper storage of Naprosyn : Store Naprosyn at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Naprosyn out of the reach of children and away from pets.

General information:

• If you have any questions about Naprosyn , please talk with your doctor, pharmacist, or other health care provider.
• Naprosyn is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Naprosyn . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Motrin is used for:

Treating rheumatoid arthritis, osteoarthritis, menstrual cramps, or mild to moderate pain. It may also be used for other conditions as determined by your doctor.

Motrin is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.

Do NOT use Motrin if:

• you are allergic to any ingredient in Motrin
• you have had a severe allergic reaction (eg, severe rash, hives, trouble breathing, growths in the nose, dizziness) to aspirin or an NSAID (eg, ibuprofen, celecoxib)
• you have recently had or will be having bypass heart surgery
• you are in the last 3 months of pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Motrin :

Some medical conditions may interact with Motrin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal product, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of kidney or liver disease, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers)
• if you have a history of swelling or fluid buildup, lupus, asthma, or growths in the nose (nasal polyps), or mouth inflammation
• if you have high blood pressure, blood disorders, bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or if you are at risk for any of these diseases
• if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you drink alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Motrin . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of stomach bleeding may be increased
• Probenecid because it may increase the risk of Motrin ’s side effects
• Cyclosporine, lithium, methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by Motrin
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by Motrin

This may not be a complete list of all interactions that may occur. Ask your health care provider if this medicine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Motrin :

Use Motrin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Motrin comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Motrin refilled.
• Take Motrin by mouth with or without food. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
• Take Motrin with a full glass of water (8 oz/240 mL) as directed by your doctor.
• If you miss a dose of Motrin and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about the proper use of Motrin .

Important safety information:

• Motrin may cause dizziness or drowsiness. These effects may be worse if you take it with alcohol or certain medicines. Use Motrin with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Serious stomach ulcers or bleeding can occur with the use of Motrin . Taking it in high doses or for a long time, smoking, or drinking alcohol increases the risk of these side effects. Taking Motrin with food will NOT reduce the risk of these effects. Contact your doctor or emergency room at once if you develop severe stomach or back pain; black, tarry stools; vomit that looks like blood or coffee grounds; or unusual weight gain or swelling.
• Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor.
• Motrin has ibuprofen in it. Before you start any new medicine, check the label to see if it has ibuprofen in it too. If it does or if you are not sure, check with your doctor or pharmacist.
• Do not take aspirin while you are using Motrin unless your doctor tells you to.
• Lab tests, including kidney function, complete blood cell counts, and blood pressure, may be done to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Motrin with caution in the ELDERLY; they may be more sensitive to its effects, including stomach bleeding and kidney problems.
• Motrin should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Motrin may cause harm to the fetus. Do not take it during the last 3 months of pregnancy. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Motrin while you are pregnant. It is not known if Motrin is found in breast milk. Do not breast-feed while taking Motrin .

Possible side effects of Motrin :

All medicines can cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache; heartburn; nausea; stomach pain or upset.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; trouble breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; chest pain; confusion; dark urine; depression; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; numbness of an arm or leg; one-sided weakness; red, swollen, blistered, or peeling skin; ringing in the ears; seizures; severe headache or dizziness; severe or persistent stomach pain or nausea; severe vomiting; shortness of breath; stiff neck; sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual bruising or bleeding; unusual joint or muscle pain; unusual tiredness or weakness; vision or speech changes; vomit that looks like coffee grounds; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center ( http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include decreased urination; loss of consciousness; seizures; severe dizziness or drowsiness; severe nausea or stomach pain; slow or troubled breathing; unusual bleeding or bruising; vomit that looks like coffee grounds.

Proper storage of Motrin :

Store Motrin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Motrin out of the reach of children and away from pets.

General information:

• If you have any questions about Motrin , please talk with your doctor, pharmacist, or other health care provider.
• Motrin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Motrin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Fosamax is used for:

Treating Paget disease. It may also be used for other conditions as determined by your doctor.

Fosamax is a bisphosphonate. It works by slowing bone loss.

Do NOT use Fosamax if:

• you are allergic to any ingredient in Fosamax
• you have certain esophagus problems (eg, narrowing, blockage)
• you are unable to stand or sit upright for at least 30 minutes
• you have low blood calcium levels or severe kidney problems

Contact your doctor or health care provider right away if any of these apply to you.

Before using Fosamax :

Some medical conditions may interact with Fosamax . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of stomach or bowel problems (eg, inflammation, ulcer), esophagus problems (eg, heartburn, reflux disease, severe irritation), or kidney problems, or if you have difficult or painful swallowing
• if you have low blood vitamin D levels, mental problems, cancer, anemia, blood clotting problems, an infection, or calcium metabolism problems
• if you have poor dental hygiene, other dental problems, or you will be having a dental procedure
• if you smoke or drink alcohol
• if you take a corticosteroid (eg, prednisone), or you have had or will be having chemotherapy or radiation treatment

Some MEDICINES MAY INTERACT with Fosamax . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen) because the risk of side effects, such as esophagus or stomach irritation, may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Fosamax may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Fosamax :

Use Fosamax as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Fosamax . Talk to your pharmacist if you have questions about this information.
• Swallow Fosamax whole. Do not break, crush, chew, or suck on the tablet before swallowing.
• Take Fosamax by mouth on an empty stomach in the morning at least 30 minutes before your first food, drink, or other medicine of the day. Do NOT take Fosamax at bedtime or before you get out of bed in the morning.
• Take Fosamax with a full glass of plain water (8 oz/240 mL). Do not take Fosamax with mineral water, coffee, tea, or juice. Do not lie down for 30 minutes after taking Fosamax and until you eat your first food of the day.
• Be sure you understand how to take Fosamax . Contact your doctor or pharmacist if you have any questions.
• Continue to use Fosamax even if you feel well. Do not miss any doses.
• If you miss a dose of Fosamax , do not take it later in the day. Take it the morning after you remember and then go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Fosamax .

Important safety information:

• Fosamax may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Fosamax with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Talk with your doctor before you drink alcohol, smoke, or use other tobacco products while taking Fosamax .
• Follow the diet and exercise program given to you by your health care provider. Talk to your doctor about whether you should take a calcium and vitamin D supplement while you use Fosamax .
• Talk to your doctor about the use of weight-bearing exercises to help prevent weak bones.
• Fosamax may cause jaw bone problems in some patients. Your risk may be greater if you have cancer, poor dental hygiene, or certain other conditions (eg, anemia, blood clotting problems, infection, dental problems). You risk may also be greater if you use certain medicines or therapies (eg, chemotherapy, corticosteroids, radiation). Talk to your doctor about having a dental exam before you start to use Fosamax . Ask your doctor any questions you may have about dental treatment while you use Fosamax .
• Proper dental care is important while you are taking Fosamax . Brush and floss your teeth and visit the dentist regularly.
• Fosamax may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Fosamax . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
• Tell your doctor or dentist that you take Fosamax before you receive any medical or dental care, emergency care, or surgery.
• Lab tests, including bone density and blood calcium levels, may be performed while you use Fosamax . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Fosamax should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Fosamax while you are pregnant. It is not known if Fosamax is found in breast milk. If you are or will be breast-feeding while you use Fosamax , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Fosamax :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Bone, muscle, or joint pain; constipation; diarrhea; dizziness; feeling bloated or full; flu-like symptoms at the start of treatment; gas; headache; mild stomach pain; nausea; taste changes; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; chest pain; coughing or vomiting blood; difficult or painful swallowing; mouth sores; new, worsening, or severe heartburn; red, swollen, blistered, or peeling skin; severe bone, muscle, or joint pain; severe or persistent sore throat or stomach pain; swelling of the hands, legs, or joints; swelling or pain in your jaw.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Drink a full glass (8 oz/240 mL) of milk. Do not lie down for at least 30 minutes or as directed by your doctor. Do not try to vomit. Symptoms may include painful swallowing; severe heartburn; stomach pain or upset.

Proper storage of Fosamax :

Store Fosamax at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Fosamax out of the reach of children and away from pets.

General information:

• If you have any questions about Fosamax , please talk with your doctor, pharmacist, or other health care provider.
• Fosamax is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Fosamax . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Evista is used for:

Treating and preventing osteoporosis (bone thinning) in women who are past menopause. It is also used to reduce the risk of invasive breast cancer in certain women who are past menopause. It may also be used for other conditions as determined by your doctor.

This medicine is a selective estrogen receptor modulator (SERM). It works in osteoporosis by decreasing bone breakdown and thinning that may occur in women after menopause. It works to decrease the risk of invasive breast cancer by blocking estrogen in breast and uterine tissue.

Do NOT use Evista if:

• you are allergic to any ingredient in Evista
• you are pregnant, could become pregnant, or are breast-feeding
• you have not yet gone through menopause
• you have a history of blood clots in your legs, lungs, or eyes
• you are taking an anion exchange resin (eg, cholestyramine, colestipol) or estrogen

Contact your doctor or health care provider right away if any of these apply to you.

Before using Evista :

Some medical conditions may interact with Evista . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of liver problems, kidney problems, breast cancer, or any other type of cancer
• if you have a history of stroke, transient ischemic attack (TIA), blood vessel problems, heart problems, (eg, heart failure, irregular heartbeat), or high blood pressure
• if you are at risk for stroke or heart problems
• if you will be having surgery, you smoke or drink alcohol, you are not able to absorb nutrients properly (gastrointestinal malabsorption syndrome), or you have very poor health
• if you are taking an estrogen or have a history of high triglyceride levels while taking an estrogen
• if anyone in your family has a history of serious blood clots

Some MEDICINES MAY INTERACT with Evista . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anion exchange resins (eg, cholestyramine) because they may decrease Evista ’s effectiveness
• Diazepam, diazoxide, or lidocaine because the risk of their side effects may be increased by Evista .
• Anticoagulants (eg, warfarin) because their effectiveness may be decreased by Evista

This may not be a complete list of all interactions that may occur. Ask your health care provider if Evista may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Evista :

Use Evista as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Evista comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Evista refilled.
• Take Evista by mouth with or without food.
• Take Evista on a regular schedule to get the most benefit from it. Taking Evista at the same time each day will help you remember to take it.
• Continue to take Evista even if you feel well. Do not miss any doses.
• If you miss a dose of Evista , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Evista .

Important safety information:

• Follow the diet and exercise program given to you by your health care provider. Talk with your doctor about whether you should take a calcium and vitamin D supplement while you use Evista .
• Talk with your doctor about the use of weight-bearing exercises to help prevent weak bones.
• Evista should be stopped at least 72 hours before surgery or any time you will be confined to a bed or chair for a long period of time (eg, long car ride, long plane flight, bedrest, illness). Tell your doctor or dentist that you take Evista before you receive any medical or dental care, emergency care, or surgery. Tell your doctor if you will be traveling, or any other time you may be confined to a bed or chair.
• If you are traveling (eg, long car ride or plane ride), try to avoid sitting in one place for a long time. Be sure to get up and move around as often as possible to help avoid the risk of blood clots.
• Evista is not recommended for use in men.
• Lab tests and medical exams, including bone density, breast exams, and mammograms, may be performed while you use Evista . They may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Evista should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not use Evista if you are pregnant. It may cause harm to the fetus. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. It is not known if Evista is found in breast milk. Do not breast-feed while taking Evista .

Possible side effects of Evista :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Hot flashes; increased sweating; joint aches; leg cramps.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abnormal vaginal bleeding; back or side pain; blurred vision, loss of vision, or other vision changes; breast pain, tenderness, swelling, lump or discharge; chest pain; coughing up blood; confusion; flu-like symptoms; leg or calf pain, warmth, or swelling; one-sided weakness; shortness of breath; slurred speech; swelling of the hands, arms, legs or feet; unexplained bleeding.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include diarrhea; dizziness; flushing; loss of coordination; severe leg cramps; tremor; vomiting.

Proper storage of Evista :

Store Evista at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Evista out of the reach of children and away from pets.

General information:

• If you have any questions about Evista , please talk with your doctor, pharmacist, or other health care provider.
• Evista is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Evista . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Estradiol should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), cancer of the uterus, and breast cancer in some women. Tell your doctor right away if you have unusual vaginal bleeding while you use Estradiol . Talk with your doctor if you have questions about the benefits and risks of using Estradiol .

Estradiol should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use Estradiol .

Estradiol is used for:

Treating conditions due to menopause (eg, hot flashes; vaginal itching, burning, or dryness), treating vulval or vaginal atrophy, and preventing osteoporosis (brittle bones). It is also used for estrogen replacement therapy after failure of the ovaries and to relieve the symptoms of breast cancer.

Treating advanced prostate cancer. It is also used to relieve symptoms of breast cancer.

Estradiol is a female estrogen hormone. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.It works for advanced prostate cancer by antagonizing male hormones.

Do NOT use Estradiol if:

• you are allergic to any ingredient in Estradiol
• you are pregnant or suspect you may be pregnant, have recently given birth or are breast-feeding, or have vaginal bleeding of abnormal or unknown cause
• you have known or suspected breast cancer (unless directed by your doctor) or you have cancers that are estrogen-dependent
• you have blood clots, vein inflammation, or liver disease
• you have had a recent stroke or heart attack

Contact your doctor or health care provider right away if any of these apply to you.

Before using Estradiol :

Some medical conditions may interact with Estradiol . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are planning to become pregnant
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a family history of breast cancer, or you have breast lumps or disease, or an abnormal mammogram
• if you have yellowing of the whites of the eyes or skin during pregnancy or with past estrogen use, or high blood pressure during pregnancy (toxemia)
• if you have a vaginal infection or womb problems (eg, uterine fibroids/endometriosis, abnormal vaginal bleeding, other uterine problems)
• if you have abnormal calcium levels in the blood, asthma, cancer, certain blood disorder (porphyria), cholesterol or lipid problems, depression, diabetes, epilepsy, excessive weight gain, gallbladder disease, heart disease or other heart problems, high blood pressure, kidney or liver disease, low thyroid hormone levels, lupus, migraine headaches, pancreas disease, seizures, or yellowing of the skin or eyes
• if you smoke or will be having surgery

Some MEDICINES MAY INTERACT with Estradiol . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Blood thinners (eg, warfarin), corticosteroids (eg, prednisone), succinylcholine, or tacrine because their actions and the risk of their side effects may be increased by Estradiol
• Blood thinners (eg, warfarin) because their effectiveness may be decreased by Estradiol
• Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or rifampin because they may decrease Estradiol ’s effectiveness

This may not be a complete list of all interactions that may occur. Ask your health care provider if Estradiol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Estradiol :

Use Estradiol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Estradiol . Talk to your pharmacist if you have questions about this information.
• Take Estradiol by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
• Grapefruit and grapefruit juice may increase the risk of Estradiol ’s side effects. Talk to your doctor before including grapefruit or grapefruit juice in your diet while you are taking Estradiol .
• If you miss a dose of Estradiol , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Estradiol .

Important safety information:

• Estradiol may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Estradiol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Limit alcoholic beverages while you are taking Estradiol .
• Estradiol may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
• Estradiol may increase the risk of blood clots. The risk may be greater if you smoke (especially in women older than 35 years of age).
• Contact your doctor if vaginal bleeding of unknown cause occurs. This could be a sign of a serious condition requiring immediate medical attention.
• Contact your doctor if vaginal discomfort occurs or if you suspect you have developed an infection while taking Estradiol .
• Follow your doctor’s instructions for examining your breasts and report any lumps immediately.
• Additional monitoring of your dose or condition may be necessary if you are presently taking an azole antifungal (eg, itraconazole), carbamazepine, a macrolide antibiotic (eg, erythromycin), ritonavir, cimetidine, or St. John’s wort.
• If you wear contact lenses and you develop problems with them, contact your doctor.
• If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Estradiol .
• Nonprescription therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor or pharmacist for more details.
• Some of these products may contain the dye tartrazine (FD&C Yellow No. 5), which can cause allergic reactions in certain patients. Consult your doctor or pharmacist. If you previously had allergic reactions to the dye tartrazine, contact your doctor or pharmacist to determine if the product you are taking contains the dye tartrazine.
• Estradiol may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Estradiol .
• Diabetes patients - Estradiol may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
• Lab tests, including physical exams and blood pressure, may be performed while you use Estradiol . You should have breast and pelvic exams, and a Pap test at least once a year. You should also have periodic mammograms as determined by your doctor. Be sure to keep all doctor and lab appointments.
• Estradiol should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
• PREGNANCY and BREAST-FEEDING: Do not use Estradiol if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Estradiol may be found in breast milk. If you are or will be breast-feeding while you use Estradiol , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Estradiol :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Breast pain or tenderness; headache; hair loss; mild nausea or vomiting; spotting or breakthrough bleeding; stomach cramps or bloating.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); back pain;breast discharge or lump in the breast; calf or leg pain or swelling; chest pain; coughing up blood; dark urine; depression; dizziness; fainting; fever; memory problems; mental or mood changes; muscle pain; one-sided weakness; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain or swelling; slurred speech; sudden shortness of breath; sunburn-like rash; swelling of hands, legs, or feet; unusual vaginal bleeding, discharge, itching, or odor; vision changes; vomiting; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include excessive vaginal bleeding; severe nausea; vomiting.

Proper storage of Estradiol :

Store Estradiol at room temperature, 59 to 86 degrees F (15 to 30 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Estradiol out of the reach of children and away from pets.

General information:

• If you have any questions about Estradiol , please talk with your doctor, pharmacist, or other health care provider.
• Estradiol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Estradiol . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Diflucan is used for:

Treating and preventing certain yeast and fungal infections. It may also be used for other conditions as determined by your doctor.

Diflucan is an azole antifungal. It kills sensitive fungi by interfering with the formation of the fungal cell membrane.

Do NOT use Diflucan if:

• you are allergic to any ingredient in Diflucan
• you are taking astemizole, an aldosterone blocker (eg, eplerenone), cisapride, an ergot alkaloid (eg, ergotamine), erythromycin, pimozide, a serotonin (5-HT1) receptor agonist (eg, eletriptan), or terfenadine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Diflucan :

Some medical conditions may interact with Diflucan . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a weakened immune system, kidney or liver disease, or an irregular heartbeat
• if you are allergic to other azole antifungals (eg, itraconazole)

Some MEDICINES MAY INTERACT with Diflucan . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Aldosterone blockers (eg, eplerenone), amiodarone, astemizole, cisapride, pimozide, serotonin receptor agonists (eg, eletriptan), macrolide antibiotics (eg, erythromycin), quinolines (eg, ciprofloxacin), or terfenadine because the risk of severe irregular heartbeat (eg, QT prolongation) may be increased
• Rifabutin because the risk of certain eye problems (eg, uveitis) may be increased
• Macrolide immunosuppressants (eg, tacrolimus) because the risk of kidney problems may be increased
• Rifampin or proton pump inhibitors (eg, omeprazole) because they may decrease Diflucan ’s effectiveness
• Anticoagulants (eg, warfarin), benzodiazepines (eg, alprazolam), buspirone, carbamazepine, cyclophosphamide, cyclosporine, ergot alkaloids (eg, ergotamine ), haloperidol, HMG-CoA reductase inhibitors or "statins" (eg, simvastatin), hydantoins (eg, phenytoin), methadone, muscarinic antagonists (eg, solifenacin, tolterodine), narcotics (eg, codeine), ramelteon, sulfonylureas (eg, glipizide), theophylline, or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Diflucan .

This may not be a complete list of all interactions that may occur. Ask your health care provider if Diflucan may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Diflucan :

Use Diflucan as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Take Diflucan by mouth with or without food.
• Take Diflucan at least 2 hours before proton pump inhibitors (eg, omeprazole).
• To clear up your infection completely, take Diflucan for the full course of treatment. Keep taking it even if you feel better in a few days. Do not miss any doses.
• Diflucan works best if it is taken at the same time each day.
• If you miss a dose of Diflucan , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Diflucan .

Important safety information:

• Diflucan may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Diflucan with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
• Diflucan has been known to cause rare cases of serious liver damage, including death, mainly in patients with serious medical conditions. Liver damage caused by Diflucan has not been attributed to total daily dose, length of therapy, or sex or age of the patient. This type of liver damage may or may not be reversible when Diflucan is stopped. If you notice any of the following, contact your doctor immediately: swollen or tender abdomen, yellowing of the skin or eyes.
• Be sure to use Diflucan for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
• Diflucan may cause a rash. If the rash worsens, contact your doctor.
• Long-term or repeated use of Diflucan may cause a second infection. Tell your doctor if signs of a second infection occur. Your medicine may need to be changed to treat this.
• Hormonal birth control (eg, birth control pills) may not work as well while you are using Diflucan . To prevent pregnancy, use an extra form of birth control (eg, condoms).
• Lab tests, such as blood urea nitrogen and liver and kidney function, may be performed while you use Diflucan . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Diflucan with caution in the ELDERLY; they may be more sensitive to its effects.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Diflucan while you are pregnant. Diflucan is found in breast milk. If you are or will be breast-feeding while you use Diflucan , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Diflucan :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in taste; dizziness; headache; nausea; stomach pain.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); diarrhea; scaly, red skin over a large portion of the body; swollen or tender abdomen; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at http://www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org/findyour.htm), or emergency room immediately. Symptoms may include changes in behavior; convulsions; hallucinations; seizures; slowed breathing.

Proper storage of Diflucan :

Store Diflucan below 86 degrees F (30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Diflucan out of the reach of children and away from pets.

General information:

• If you have any questions about Diflucan , please talk with your doctor, pharmacist, or other health care provider.
• Diflucan is to be used only by the patient for whom it is prescribed. Do not share it with other people.
• If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Diflucan . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.